LIFE SCIENCE

Gene-edited dairy goats enrich the nutritional value of goat’s milk


Photo by Tian Huibin, SCD1 gene-edited dairy goat at the Animal Husbandry Teaching Experimental Base of Northwest A&F University in Yangling, Shaanxi

Photo by Tian Huibin, SCD1 gene-edited dairy goat at the Animal Husbandry Teaching Experimental Base of Northwest A&F University in Yangling, Shaanxi

Professor Luo Jun’s team from the College of Animal Science and Technology of Northwest A&F University and the huajinlian researcher team of the College of Veterinary Medicine cooperated to prepare SCD1 gene-edited Sinong Saneng dairy goat using CRISPR/Cas9 gene editing technology, which changed the composition of saturated fatty acids and unsaturated fatty acids in goat milk, which is of great significance in the breeding of high-quality dairy goats and the quality control of goat milk. The research was recently published in the Journal of Agricultural and Food Chemistry.

“Goat milk is rich in saturated and unsaturated fatty acids, which can reduce blood cholesterol deposition, has a certain health care effect on diseases such as hyperlipidemia and nutritional deficiency, and is also an important embodiment of the nutritional value of goat milk and the quality of goat milk.” Tian Huibin, the first author of the study and a postdoctoral fellow from Luo Jun’s team, introduced to China Science News that the key gene regulating the synthesis of unsaturated fatty acids in goat milk is the stearoyl-CoA desaturase 1 (SCD1) gene, which can affect the composition and proportion of saturated and unsaturated fatty acids in goat milk, and these fatty acids are important components and embodiments of goat milk quality. Therefore, the cultivation of new breeds and new strains of dairy goats through genetic improvement means can produce high-quality goat milk with rich nutritional value.

Dairy is an important strategic industry for agricultural modernization, goat milk due to its high nutritional value, easy to absorb, low sensitization and other characteristics, more and more favored by consumers, market demand is increasing day by day. With the development and innovation of gene editing technology, it has also shown a strong application role in the field of animal breeding. “The use of CRISPR/Cas9 technology combined with fertilized egg microinjection and embryo transfer, the obtained SCD1 gene edited dairy goat, the saturated fatty acid content in goat milk increased, the content of unsaturated fatty acids decreased, and the nutritional composition of goat milk was realized through genetic means, which greatly shortened the breeding cycle of dairy goats, and at the same time achieved the purpose of regulating the quality of goat milk.” The study’s co-corresponding author Hua Jinlian introduced.

In this study, by analyzing the interaction network between sheep milk lipid group and gene expression regulation, the function of SCD1 gene in goat milk fatty acid metabolism and lipid synthesis was clarified, and the regulatory network of SCD1 gene influencing goat milk fatty acid metabolism was found. “The research results laid a foundation for the study of the genetic basis of dairy goat milk quality traits from the cell level to the living level, revealed the formation mechanism of unsaturated fatty acids in goat milk, and also provided key technical support and important experimental reference for the cultivation of new gene-edited dairy goat breeds with important breeding value, which is of great significance for solving the bottleneck problem of sheep milk quality improvement and the breeding of high-quality dairy goats.” Luo Jun, co-corresponding author of the study, introduced the significance and application value of breeding gene-edited dairy goats. (Source: China Science Daily Feng Lifei)

Related paper information:https://doi.org/10.1021/acs.jafc.2c00642


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